General
Preferred name
AMG-18
Synonyms
AMG 18 hydrochloride ()
Ire-1 inhibitor ()
QFV ()
Kira8 ()
Ire-1 inhibitor,AMG-18 ()
AMG 18 ()
AMG 18 (hydrochloride) ()
P&D ID
PD120171
CAS
2250019-92-0
1630086-20-2
Tags
available
probe
Probe info
Probe type
calculated probe
experimental probe
P&D approved
Probe selectivity
protein-selective
Probe sources
Chemical Probes.org
High-quality chemical probes
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Kira8 (AMG-18) is a mono-selective IRE1¦Á inhibitor that allosterically attenuates IRE1¦Á RNase activity with an IC50 of 5.9 nM[1].
PRICE 359
DESCRIPTION Kira8 (AMG-18) is a mono-selective IRE1?? inhibitor that allosterically attenuates IRE1?? RNase activity with an IC50 of 5.9 nM.
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION Potent and selective SUV420H1/H2 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
11
Cayman Chemical Bioactives
43488
Chemical Probes.org
amg-18
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
EOS100542
EUbOPEN Chemogenomics Library
EUB0001858
High-quality chemical probes
PD120171
MedChem Express Bioactive Compound Library
HY-114368
Probe Miner (suitable probes)
O75460/873758
Selleckchem Bioactive Compound Library
kira8
TargetMol Bioactive Compound Library
T11762L
Tocris Bioactive Compound Library
6166
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
600.17
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
6
Aromatic Ring Count
5
cLogP
6.41
TPSA
118.13
Fraction CSP3
0.19
Chiral centers
1.0
Largest ring
6.0
QED
0.19
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
IRE1
IRE1α
ERN1
MOA
Inhibitor
Target class
Protein kinase
Kinase
Pathway
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
Target subclass
Ser/Thr Kinase
Recommended Cell Concentration
1 uM
Source data